DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated from cerebral venous blood during electrically induced sleep. It is researched for slow-wave sleep architecture, HPA-axis modulation and neuroprotective antioxidant pathways in preclinical models.

Is DSIP legal to buy in the UK?

Yes — for in-vitro laboratory research only. DSIP is not a licensed medicine and not approved by the MHRA for human or veterinary use. Buyers must be 18+.

Store the lyophilised vial at -20°C, sealed and protected from light. After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within 28 days.

What purity does Peptides UK DSIP meet?

Every DSIP 5mg vial is independently HPLC-UV verified to ≥98% purity with mass-spectrometry identity confirmation. Signed CoA supplied with every order.

What research does DSIP support?

Published research has investigated DSIP in slow-wave sleep architecture, HPA-axis and cortisol modulation, oxidative-stress neuroprotection, and anticonvulsant activity in seizure models.

Where can I buy DSIP in the UK?

This page is where UK researchers buy DSIP 5mg directly — stocked and dispatched from Manchester, ≥98% HPLC-verified with a signed Certificate of Analysis, and same-day dispatch on orders before 6pm GMT.

For Research Purposes Only · Not For Human Consumption

Must be 18+ · Batch CoA Available · Royal Mail Tracked

Batch-Matched CoA Available

Research Use Only · Not For Human Consumption

Same-Day Dispatch from Manchester

Independently Tested · Janoshik & Aspen Bio

Stored at −20°C Until Dispatch

Home/Buy/DSIP 5mg

Sleep Research≥98% HPLC

Lot —

Third-party tested

CoA available

UK dispatched

CoA verified

Sleep / Neuropeptide Research

Buy DSIP 5mg UK | Research Grade

Name: DSIP 5mg
Brand: Peptides UK
SKU: PB-DSIP-5MG
Price: 13.99 GBP
Availability: InStock

Delta Sleep-Inducing Peptide. Nonapeptide studied for slow-wave sleep architecture, stress response and neuroendocrine modulation.

£13.99

In stock

Inc. VAT · Add £36.01 more for free UK shipping

SSL encrypted · Same-day dispatch before 6pm · CoA on this lot

Order before 6pm tomorrow for same-day dispatch

Independently HPLC-tested. Lot-matched CoA available on request — quote your batch and order ID.

What ships with your order

011 × DSIP 5mg — lyophilised, sealed glass vial
02Signed CoA — batch this lot, HPLC-UV + mass-spec
03Royal Mail Tracked 24 — same-day dispatch before 6pm, Mon–Fri

Research Compound

About DSIP

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated from rabbit cerebral venous blood during electrically induced sleep by Monnier and Schoenenberger (1977). Research has investigated DSIP in slow-wave sleep architecture, stress-response modulation, hypothalamic-pituitary-adrenal axis regulation and antioxidant pathways. ≥98% HPLC, third-party CoA.

Research areas

Slow-wave sleep models
HPA-axis modulation
Stress-response research
Antioxidant pathways
Neuroendocrine studies

Compound Profile

DSIP 5mg — mechanism, research applications & compound data

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated from rabbit cerebral venous blood during electrically induced sleep by Monnier and Schoenenberger (1977). Extensively researched for slow-wave sleep architecture, stress-response modulation, HPA-axis regulation and antioxidant pathways. Peptides UK supplies DSIP 5mg as ≥98% HPLC lyophilised powder with a signed third-party Certificate of Analysis.

What is DSIP? A sleep-associated nonapeptide

DSIP is the nine-amino-acid peptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, originally identified in cerebral venous blood collected from rabbits during electrical stimulation of the thalamus that induced sleep. The peptide's specific mechanism of action remains an open research question — despite decades of investigation, no dedicated 'DSIP receptor' has been definitively characterised — which has made it a persistent object of study in the neuropeptide literature.

DSIP mechanism and research pathways

Published research has documented DSIP's association with slow-wave (delta) sleep architecture in EEG studies, modulation of the hypothalamic-pituitary-adrenal (HPA) axis, protective effects against oxidative stress in neuronal cell models, modulation of somatostatin and beta-endorphin release, and anticonvulsant activity in seizure models. The absence of an identified receptor suggests DSIP may act through multiple upstream neuroendocrine pathways rather than a single defined signalling target.

DSIP research applications

Published research has investigated DSIP in slow-wave sleep and EEG-architecture studies, HPA-axis and cortisol-modulation research, antioxidant and neuroprotection models, stress-response modelling, and chronic-pain and seizure-model research. It is one of the few research peptides with a documented sleep-modulatory profile in preclinical work.

Reconstitution and stability

Store the lyophilised vial at -20°C, sealed and protected from light. Reconstitute with bacteriostatic water (0.9% benzyl alcohol) — typically 1ml per 5mg vial. Add solvent slowly down the side of the vial; do not shake. Refrigerate the reconstituted solution at 2–8°C and use within 28 days. Do not refreeze.

≥98% HPLC purity

Every DSIP 5mg vial is independently HPLC-UV tested to ≥98% purity by Janoshik Analytical or Aspen Bioanalytics, with mass-spectrometry identity confirmation against the published molecular weight of 848.83 Da. The signed PDF CoA is supplied with every order.

Why Peptides UK for DSIP

UK-stocked, same-day Manchester dispatch, third-party HPLC verification on every batch and Royal Mail Tracked 24 with insulated cold-chain packaging. Full lot traceability from vial sticker to signed CoA on this product page.

Related search terms

buy DSIP UK
DSIP 5mg
delta sleep inducing peptide UK
DSIP for sale UK
sleep research peptide
DSIP HPLC verified
DSIP CoA
buy DSIP
DSIP peptide UK
where to buy DSIP

References & further reading

Primary sources cited on this page

Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu), first isolated from rabbit cerebral venous blood in 1977 by Monnier and Schoenenberger during electrically-induced sleep experiments. Despite four decades of investigation, no specific DSIP receptor has been definitively characterised.

Peer-reviewed literature & regulatory records

[1] Schoenenberger & Monnier, 'Characterization of a delta-electroencephalogram (-sleep)-inducing peptide'
Proceedings of the National Academy of Sciences, 1977;74(3):1282-1286
[2] Kovalzon & Strekalova, 'Delta sleep-inducing peptide (DSIP): a still unresolved riddle'
Journal of Neurochemistry, 2006;97(2):303-9
[3] Graf & Kastin, 'Delta-sleep-inducing peptide (DSIP): a review'
Neuroscience & Biobehavioral Reviews, 1984;8(1):83-93
[4] PubChem CID 68816 — DSIP
NCBI PubChem

Related research compounds

Regulatory & compliance notice

This product is supplied strictly for in-vitro laboratory research. It is not a licensed medicine in the United Kingdom, is not approved by the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency for human or veterinary use, and is not intended to diagnose, treat, cure or prevent any disease. Nothing on this page constitutes medical advice.

External links point to primary literature or regulatory records and open in a new tab. Citations are provided so the reader can independently verify every factual claim made on this page. Last reviewed 22 July 2026.

Certificate of Analysis

DSIP 5mg

Independent lab: Janoshik Analytical
Batch number: —
Method: HPLC-UV + MS
Result: ≥98% HPLC

Download CoA (PDF) — DSIP 5mg

The CoA you download is the exact certificate produced for this lot — no edits.

Storage & handling

Keep it stable, keep it sterile

Storage: Store lyophilised powder at -20°C in a sealed vial. Protect from light and moisture. Allow the vial to reach room temperature before opening to prevent condensation entering the vial. Do not store in a frost-free freezer.
Reconstitution: Reconstitute using bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the side of the vial — do not shake. Allow to dissolve gently at room temperature.
Reconstituted stability: Once reconstituted, store at 2–8°C (refrigerated). Use within 28 days. Do not refreeze after reconstitution.
Shipping: All vials are dispatched in insulated mailers with ice packs to maintain cold chain during Royal Mail Tracked 24 transit.

+ Add Bacteriostatic Water (£4.99) →

FAQ

DSIP 5mg — common questions

Researchers also ordered

View all →

Anxiolytic
Nootropic / Anxiolytic Research
Selank · 10mg
Synthetic tuftsin-derived heptapeptide. Studied for GABAergic modulation, anxiolytic response and BDNF expression without sedation.
≥98% HPLCIn Stock
£24.99
View Product
Nootropic
Nootropic / Cognitive Research
Semax · 10mg
Synthetic ACTH(4-10) analogue. Researched for BDNF expression, focus, memory and neuroprotection in preclinical models.
≥98% HPLCIn Stock
£24.99
View Product
Essential
Accessories / Reconstitution
Bacteriostatic Water · 3ml
0.9% benzyl alcohol bacteriostatic water for peptide reconstitution. Pharmaceutical-grade, sterile-filtered 3ml vial.
≥98% HPLCIn Stock
£4.99
View Product

Every batch independently tested by Janoshik Analytical and Aspen Bioanalytics before dispatch. Signed certificates available on every product page.

Third-party HPLC-UV testing Lot-matched CoA on every order Batch-traceable from dispatch

Legal notice

This product is sold strictly for in-vitro laboratory research purposes only. It is not approved for human or veterinary use, is not a drug, food, or cosmetic, and should not be misused as such. Peptides UK accepts no liability for misuse. By purchasing you confirm you are a qualified researcher aged 18 or over.

DSIP 5mg

£13.99