For Research Purposes Only · Not For Human Consumption

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Nootropic≥98% HPLC
Lot —
Semax 10mg vial
Third-party tested
CoA available
UK dispatched
CoA verified

Nootropic / Cognitive Research

Buy Semax 10mg UK | Research Grade

Synthetic ACTH(4-10) analogue. Researched for BDNF expression, focus, memory and neuroprotection in preclinical models.

£24.99

In stock

Inc. VAT · Add £25.01 more for free UK shipping

1

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Order before 6pm tomorrow for same-day dispatch

Independently HPLC-tested. Lot-matched CoA available on request — quote your batch and order ID.

What ships with your order

  • 011 × Semax 10mg — lyophilised, sealed glass vial
  • 02Signed CoA — batch this lot, HPLC-UV + mass-spec
  • 03Royal Mail Tracked 24 — same-day dispatch before 6pm, Mon–Fri
Research Compound

About Semax

Semax is a synthetic heptapeptide developed at the Russian Academy of Sciences, derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH(4-10)) with a Pro-Gly-Pro C-terminal extension for enzymatic stability. Extensively studied for BDNF and NGF upregulation, dopaminergic modulation and neuroprotective activity in in-vitro and preclinical models. ≥98% HPLC, third-party CoA on every batch.

Research areas

  • BDNF & NGF expression
  • Neuroprotection
  • Attention & memory
  • Dopaminergic modulation
  • Stroke recovery models
Compound Profile

Semax 10mg — mechanism, research applications & compound data

Semax is a synthetic heptapeptide analogue of the N-terminal fragment of adrenocorticotropic hormone (ACTH(4-10)), developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. Extensively researched for BDNF and NGF upregulation, dopaminergic modulation and neuroprotective activity in preclinical models. Peptides UK supplies Semax 10mg as ≥98% HPLC lyophilised powder with a signed third-party Certificate of Analysis.

01

What is Semax? An ACTH(4-10) heptapeptide analogue

Semax consists of the biologically active ACTH(4-10) fragment (Met-Glu-His-Phe) extended with a C-terminal Pro-Gly-Pro sequence to confer resistance to enzymatic degradation. It was developed as a stable research analogue of the endogenous ACTH-derived neuropeptides implicated in learning, memory and stress response. Semax is listed on the World Health Organisation's INN registry and has been widely researched in the Russian and international neuroscience literature.

02

Semax mechanism of action in research models

Published research has documented rapid upregulation of BDNF and NGF expression in hippocampal and cortical tissue, modulation of dopaminergic and serotonergic systems, protection of neuronal cells from ischaemic and oxidative injury in stroke models, enhancement of enkephalin-mediated pain-modulation pathways, and activation of the melanocortin receptor system. These converging effects make Semax an unusually versatile reference compound in cognitive and neuroprotective research.

03

Semax research applications

Published research has investigated Semax in attention, learning and memory models, BDNF and neurotrophic factor studies, ischaemic stroke recovery models, ADHD and executive-function research, neuroprotection in oxidative-stress paradigms, and comparative pharmacology against Selank and other Russian-origin research nootropics. The 10mg vial supports typical research-scale protocols at standard reconstitution concentrations.

04

Reconstitution, storage and stability

Store the lyophilised vial at -20°C, sealed and protected from light. Reconstitute with bacteriostatic water (0.9% benzyl alcohol) — typically 1–2ml per 10mg vial. Add solvent down the side of the vial slowly; do not agitate. Refrigerate the reconstituted solution at 2–8°C and use within 28 days. Do not refreeze.

05

≥98% HPLC purity verified independently

Every Semax 10mg vial is independently HPLC-UV tested to ≥98% purity by Janoshik Analytical or Aspen Bioanalytics, with mass-spectrometry identity confirmation against the published molecular weight of 813.94 Da. The signed PDF Certificate of Analysis is supplied with every order and matches the lot number on the vial.

06

Why Peptides UK for Semax

Semax is one of the most-counterfeited nootropic research peptides on the grey market, with under-dosed vials and substituted compounds widespread. Peptides UK counters this with mandatory third-party HPLC verification, UK-stocked inventory, same-day Manchester dispatch and Royal Mail Tracked 24 cold-chain delivery.

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References & further reading

Primary sources cited on this page

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) analogue of the ACTH(4-10) fragment, developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It is on the World Health Organisation's International Nonproprietary Names list. Semax is registered as a medicine in the Russian Federation but is not licensed by the MHRA, EMA or FDA.

Peer-reviewed literature & regulatory records

  1. [1] Ashmarin et al., 'Nootropic and analeptic drug Semax based on ACTH(4-10) fragment: 15 years of experience'
    Voprosy Meditsinskoi Khimii, 1997;43(3):200-3
  2. [2] Dolotov et al., 'Semax, an analog of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain'
    Journal of Neurochemistry, 2006;97 Suppl 1:82-6
  3. [3] Gusev et al., 'Semax in prevention of disease progress and development of exacerbations in patients with cerebrovascular insufficiency'
    Zh Nevrol Psikhiatr Im S S Korsakova, 2005;105(2):35-40
  4. [4] WHO INN 71 — Recommended International Nonproprietary Names
    WHO Drug Information
  5. [5] PubChem CID 108195 — Semax
    NCBI PubChem

Analytical & handling guides

Regulatory & compliance notice

This product is supplied strictly for in-vitro laboratory research. It is not a licensed medicine in the United Kingdom, is not approved by the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency for human or veterinary use, and is not intended to diagnose, treat, cure or prevent any disease. Nothing on this page constitutes medical advice.

External links point to primary literature or regulatory records and open in a new tab. Citations are provided so the reader can independently verify every factual claim made on this page. Last reviewed 22 July 2026.

Certificate of Analysis

Semax 10mg

Independent lab
Janoshik Analytical
Batch number
—
Method
HPLC-UV + MS
Result
≥98% HPLC
Download CoA (PDF) — Semax 10mg

The CoA you download is the exact certificate produced for this lot — no edits.

Storage & handling

Keep it stable, keep it sterile

  • Storage: Store lyophilised powder at -20°C in a sealed vial. Protect from light and moisture. Allow the vial to reach room temperature before opening to prevent condensation entering the vial. Do not store in a frost-free freezer.
  • Reconstitution: Reconstitute using bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the side of the vial — do not shake. Allow to dissolve gently at room temperature.
  • Reconstituted stability: Once reconstituted, store at 2–8°C (refrigerated). Use within 28 days. Do not refreeze after reconstitution.
  • Shipping: All vials are dispatched in insulated mailers with ice packs to maintain cold chain during Royal Mail Tracked 24 transit.
+ Add Bacteriostatic Water (£4.99) →
FAQ

Semax 10mg — common questions

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    Bacteriostatic Water · 3ml

    0.9% benzyl alcohol bacteriostatic water for peptide reconstitution. Pharmaceutical-grade, sterile-filtered 3ml vial.

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Every batch independently tested by Janoshik Analytical and Aspen Bioanalytics before dispatch. Signed certificates available on every product page.

Third-party HPLC-UV testing Lot-matched CoA on every order Batch-traceable from dispatch

Legal notice

This product is sold strictly for in-vitro laboratory research purposes only. It is not approved for human or veterinary use, is not a drug, food, or cosmetic, and should not be misused as such. Peptides UK accepts no liability for misuse. By purchasing you confirm you are a qualified researcher aged 18 or over.

Semax 10mg

£24.99