Buy Glutathione 1500mg UK | Research Grade

Glutathione is a small tripeptide of glutamate, cysteine and glycine, distinguished by an unusual γ-carboxyl peptide bond between glutamate and cysteine that confers resistance to peptidase degradation. Cellular concentrations are exceptionally high — typically 1–10mM inside cells — making it the dominant redox buffer of intracellular biology. It exists in equilibrium between the reduced (GSH) and oxidised disulphide (GSSG) forms; the GSH:GSSG ratio is a widely-used biomarker of oxidative stress in research.

Glutathione's cysteine thiol group is the reactive centre for redox reactions, scavenging reactive oxygen species directly, serving as substrate for glutathione peroxidases in peroxide detoxification, and forming conjugates with electrophilic xenobiotics via glutathione S-transferases in phase-II detoxification. Additionally, glutathione inhibits tyrosinase in melanocyte research models, which underlies its use as a reference compound in melanogenesis and skin brightening research.

Published research has investigated glutathione in oxidative-stress and redox-biology models, hepatic phase-II detoxification research, tyrosinase and melanogenesis regulation, mitochondrial-function studies, glutathione peroxidase and glutathione reductase enzyme research, and comparative antioxidant pharmacology against N-acetyl cysteine and other thiol antioxidants.

Store the lyophilised glutathione powder at -20°C, sealed and protected from light. Reduced glutathione oxidises rapidly on exposure to air — keep vials tightly sealed and reconstitute immediately before use where possible. Reconstitute with bacteriostatic water (0.9% benzyl alcohol). Refrigerate the reconstituted solution at 2–8°C and use within 14 days. For longer storage, aliquot and freeze at -20°C.

Every Glutathione 1500mg lot is independently HPLC-UV tested to ≥98% purity by Janoshik Analytical or Aspen Bioanalytics, with mass-spectrometry identity confirmation against the published molecular weight of 307.32 Da (reduced form). The signed PDF Certificate of Analysis is supplied with every order.

Glutathione is particularly sensitive to poor storage — a vial oxidised in transit is analytically inferior before it reaches your bench. Peptides UK ships with insulated mailers and ice packs, dispatches same-day from Manchester and provides third-party HPLC verification on every batch confirming reduced-form purity at the point of dispatch.