Buy IGF-1 LR3 1mg UK | Research Grade

Native human IGF-1 is a 70-amino-acid single-chain protein that circulates largely bound to IGF-binding proteins (IGFBPs), which regulate its bioavailability. IGF-1 LR3 modifies this profile by adding a 13-amino-acid MFPAMPLSSLFVN extension to the N-terminus and substituting arginine for glutamate at position 3 — the two changes together produce an analogue with dramatically reduced IGFBP affinity and correspondingly higher free-fraction bioactivity per unit dose in in-vitro research models.

IGF-1 LR3 binds the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase, triggering autophosphorylation and activation of the PI3K/Akt/mTOR and Ras/MAPK downstream signalling cascades. In muscle cell models, this drives myoblast proliferation, differentiation and hypertrophic protein synthesis. In hepatocyte research, it modulates gluconeogenesis and metabolic gene expression. Its reduced IGFBP binding means it acts on IGF-1R with less regulatory buffering than native IGF-1 in the same experimental system.

Published research has investigated IGF-1 LR3 in myogenesis and satellite-cell activation, muscle hypertrophy and protein-synthesis research, PI3K/Akt/mTOR signalling studies, comparative pharmacology against native IGF-1 and MGF (mechano growth factor), pancreatic beta-cell research, and cell-line proliferation assays. The 1mg vial supports typical research-scale in-vitro protocols; higher payloads are unusual because IGF-1 LR3 is highly potent per unit mass.

Store the lyophilised vial at -20°C, sealed and protected from light. Reconstitute with bacteriostatic water (0.9% benzyl alcohol) — some research protocols use acidified diluents (dilute acetic acid) to maximise long-term stability of IGF-1 analogues; either is acceptable at research scale. Refrigerate the reconstituted solution at 2–8°C and use within 14 days. For longer storage, aliquot and freeze at -20°C.

Every IGF-1 LR3 1mg vial is independently HPLC-UV tested to ≥98% purity by Janoshik Analytical or Aspen Bioanalytics, with mass-spectrometry identity confirmation against the published molecular weight of approximately 9,111 Da. The signed PDF Certificate of Analysis is supplied with every order and matches the vial lot number.

Recombinant growth-factor analogues are particularly sensitive to transit temperature — a vial that has warmed above 4°C for extended periods may show degradation before it reaches the bench. Peptides UK stocks IGF-1 LR3 in temperature-controlled storage, dispatches same-day in insulated cold-chain mailers and provides third-party HPLC verification on every batch.