For Research Purposes Only · Not For Human Consumption
Mitochondrial / Metabolic Research
16-amino-acid mitochondrial-derived peptide. Studied for AMPK activation, insulin sensitivity and metabolic homeostasis.
£24.99
In stockInc. VAT · Add £25.01 more for free UK shipping
SSL encrypted · Same-day dispatch before 6pm · CoA on this lot
Independently HPLC-tested. Lot-matched CoA available on request — quote your batch and order ID.
What ships with your order
MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA type-C) is a 16-amino-acid peptide encoded within the mitochondrial genome. First characterised by Cohen et al. (2015), MOTS-C acts as an AMPK activator and is one of the most researched mitochondrial-derived peptides in metabolic pathway biology. ≥98% HPLC, batch-matched CoA.
MOTS-C is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the 12S ribosomal RNA region of the mitochondrial genome, first characterised by Cohen et al. (2015). Research has established MOTS-C as an AMPK activator with documented effects on insulin sensitivity, glucose homeostasis and mitochondrial biogenesis — earning it the label 'exercise mimetic' in the metabolic literature. Peptides UK supplies MOTS-C 10mg as ≥98% HPLC lyophilised powder with a signed third-party CoA.
MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA type-C) is one of a growing family of mitochondrial-derived peptides — bioactive peptides encoded within the mitochondrial genome rather than the nuclear DNA. Its discovery challenged the conventional view that mitochondria encode only structural proteins and highlighted the mitochondrion as an active endocrine organelle.
Research has documented MOTS-C activation of AMP-activated protein kinase (AMPK), the central cellular energy sensor. Downstream effects observed in in-vitro and animal models include enhanced insulin sensitivity, increased glucose disposal, mitochondrial biogenesis via PGC-1α upregulation, and translocation to the nucleus under metabolic stress where it modulates stress-response gene expression. These effects align mechanistically with metformin and exercise-mimetic pathways.
Published research has investigated MOTS-C in insulin sensitivity and diabetes models, obesity and metabolic syndrome research, exercise-mimetic pathway studies, mitochondrial biogenesis and PGC-1α signalling, cellular stress and longevity research, and comparative metabolic peptide pharmacology alongside Humanin and SHLP peptides. The 10mg vial supports extended research protocols.
Store the lyophilised vial at -20°C, sealed and protected from light. Reconstitute with bacteriostatic water (0.9% benzyl alcohol) — typically 1–2ml per 10mg vial. Add solvent slowly; do not shake. Refrigerate the reconstituted solution at 2–8°C and use within 28 days. Do not refreeze after reconstitution.
Every MOTS-C 10mg vial is independently HPLC-UV tested to ≥98% purity by Janoshik Analytical or Aspen Bioanalytics, with mass-spectrometry identity confirmation against the published molecular weight of approximately 2,174.6 Da. The signed PDF CoA is supplied with every order.
UK stock, same-day Manchester dispatch before 6pm GMT, Royal Mail Tracked 24 with insulated cold-chain packaging, and mandatory third-party HPLC verification on every batch. The most reliable UK source for research-grade MOTS-C with verifiable analytical data.
Related search terms
MOTS-c is a 16-residue peptide encoded within the 12S ribosomal RNA region of the mitochondrial genome — one of a small family of mitochondrial-derived peptides (MDPs) characterised by Cohen and colleagues. Research has established MOTS-c as an AMP-activated protein kinase (AMPK) activator in cell and animal models.
Regulatory & compliance notice
This product is supplied strictly for in-vitro laboratory research. It is not a licensed medicine in the United Kingdom, is not approved by the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency for human or veterinary use, and is not intended to diagnose, treat, cure or prevent any disease. Nothing on this page constitutes medical advice.
External links point to primary literature or regulatory records and open in a new tab. Citations are provided so the reader can independently verify every factual claim made on this page. Last reviewed 22 July 2026.
Certificate of Analysis
MOTS-C 10mg
The CoA you download is the exact certificate produced for this lot — no edits.
Storage & handling
Keep it stable, keep it sterile
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Accessories / Reconstitution
Bacteriostatic Water · 3ml0.9% benzyl alcohol bacteriostatic water for peptide reconstitution. Pharmaceutical-grade, sterile-filtered 3ml vial.
£4.99
Every batch independently tested by Janoshik Analytical and Aspen Bioanalytics before dispatch. Signed certificates available on every product page.
Legal notice
This product is sold strictly for in-vitro laboratory research purposes only. It is not approved for human or veterinary use, is not a drug, food, or cosmetic, and should not be misused as such. Peptides UK accepts no liability for misuse. By purchasing you confirm you are a qualified researcher aged 18 or over.
MOTS-C 10mg
£24.99